Extremely Low Hit Rate in a Diverse Chemical Drug Screen Targeting Mycobacterium abscessus

Antimicrob Agents Chemother. 2019 Oct 22;63(11):e01008-19. doi: 10.1128/AAC.01008-19. Print 2019 Nov.

Jakob J Malin^{1

2}, Sandra Winter^{1

2}, Edeltraud van Gumpel^{1

2}, Georg Plum³, Jan Rybniker^{4

2

5}

¹ Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.
² Faculty of Medicine, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
³ Faculty of Medicine and University Hospital of Cologne, Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany.
⁴ Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany [email protected].
⁵ German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.

No abstract available

Keywords: Mycobacterium abscessus; NTM; drug discovery; drug screening; emerging pathogens; hit rate.

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