A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

M C Nussenzweig; E V Schmidt; A C Shaw; E Sinn; J Campos-Torres; B Mathey-Prevot; P K Pattengale; P Leder

doi:10.1038/336446a0

A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

Nature. 1988 Dec 1;336(6198):446-50. doi: 10.1038/336446a0.

Authors

M C Nussenzweig¹, E V Schmidt, A C Shaw, E Sinn, J Campos-Torres, B Mathey-Prevot, P K Pattengale, P Leder

Affiliation

¹ Department of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts.

PMID: 3143076
DOI: 10.1038/336446a0

Abstract

Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig mu is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abelson murine leukemia virus
Animals
B-Lymphocytes / metabolism
B-Lymphocytes / pathology
Bone Marrow / pathology
Cell Transformation, Neoplastic
Cell Transformation, Viral
Enhancer Elements, Genetic
Genes, Immunoglobulin*
Hematopoietic Stem Cells / metabolism
Humans
Immunoglobulin mu-Chains / genetics
Lymphoma / genetics*
Lymphoma / immunology
Lymphoma / pathology
Mice
Mice, Transgenic
Phenotype
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-myc
Proto-Oncogenes*
RNA, Messenger / metabolism

Substances

Immunoglobulin mu-Chains
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-myc
RNA, Messenger