A Role for IL-12 in IBD after All?

Carrie N Arnold Greving; Jennifer E Towne

doi:10.1016/j.immuni.2019.07.008

A Role for IL-12 in IBD after All?

Immunity. 2019 Aug 20;51(2):209-211. doi: 10.1016/j.immuni.2019.07.008.

Authors

Carrie N Arnold Greving¹, Jennifer E Towne²

Affiliations

¹ Immunology Discovery, Janssen Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA.
² Immunology Discovery, Janssen Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA. Electronic address: [email protected].

PMID: 31433967
DOI: 10.1016/j.immuni.2019.07.008

Abstract

The interplay between intestinal epithelial barrier function, the intestinal microbiota, and cytokine signaling in the pathogenesis of inflammatory bowel disease is not completely understood. In this issue of Immunity, Eftychi et al. examined the cell types and cytokines that drive colitis in mice with an intestinal epithelial barrier defect and uncovered a surprising role for IL-12 in initiation of disease.

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MeSH terms

Animals
Colitis*
Cytokines
Inflammation
Inflammatory Bowel Diseases*
Interleukin-12
Interleukin-23
Intestinal Mucosa
Mice

Substances

Cytokines
Interleukin-23
Interleukin-12