Compatibility of 5-ethynyl-2'F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers

Affiliations

• ¹ Institut Pasteur, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, CNRS UMR 3523, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France. [email protected] and Institut Pasteur, Department of Genome and Genetics, Paris, France.
• ² Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland and Department of Chemistry, McGill University, 801 Rue Sherbrooke Street West, Montréal, QC H3A 0B8, Canada.
• ³ Institut Pasteur, Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur, USR 3756 CNRS, Paris, France and Institut Pasteur, Biomics Platform, C2RT, Paris, France.
• ⁴ Department of Chemistry, McGill University, 801 Rue Sherbrooke Street West, Montréal, QC H3A 0B8, Canada.
• ⁵ Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.