Background: Danaparoid sodium and synthetic protease inhibitors (SPIs) have been approved for the treatment of disseminated intravascular coagulation (DIC) in Japan.
Objectives: To compare the clinical results of the treatment of DIC with danaparoid or SPIs.
Methods: We retrospectively examined 188 patients with hematological malignancy-related DIC.
Results: DIC resolution rate in the danaparoid group was higher than that in the SPIs group (61.5 vs. 42.6%; p = 0.031) on day 7. Multivariate analysis identified the response to chemotherapy as independent predictive factor for DIC resolution on day 7 (odds ratio, OR, 2.28; 95% confidence interval, CI, 1.21-4.31; p = 0.011). While there was no significant difference in the DIC resolution rate on day 14 (75.0 vs. 62.4%; p = 0.117), in a subgroup analysis of patients who did not show an improvement in the underlying disease, the danaparoid group showed a significantly better DIC resolution rate (OR 3.89; 95% CI 1.15-13.2; p = 0.030). There was no difference in the rate of cumulative mortality from bleeding within 28 days between the 2 groups (6.6 vs. 3.3%; p = 0.278).
Conclusions: Danaparoid may be associated with more frequent resolution of DIC in patients with refractory underlying disease.
Keywords: Danaparoid sodium; Disseminated intravascular coagulation; Gabexate mesilate; Hematological malignancy; Nafamostat mesilate; Synthetic protease inhibitors.
© 2019 S. Karger AG, Basel.