Humoral Immune Deficiencies of Childhood

Marwa El-Bohy; Pavadee Poowuttikul; Elizabeth Secord

doi:10.1016/j.pcl.2019.06.010

Humoral Immune Deficiencies of Childhood

Pediatr Clin North Am. 2019 Oct;66(5):897-903. doi: 10.1016/j.pcl.2019.06.010.

Authors

Marwa El-Bohy¹, Pavadee Poowuttikul¹, Elizabeth Secord²

Affiliations

¹ Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, 3950 Beaubien Boulevard, Detroit, MI 48201, USA.
² Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, 3950 Beaubien Boulevard, Detroit, MI 48201, USA. Electronic address: [email protected].

PMID: 31466679
DOI: 10.1016/j.pcl.2019.06.010

Abstract

The most common primary immune deficiencies are those of the humoral immune system, and most of these present in childhood. The severity of these disorders ranges from transient deficiencies to deficiencies that are associated with a complete loss of ability to make adequate or functional antibodies, and have infectious as well as noninfectious complications. This article reviews, in a case-based discussion, the most common of the humoral immune deficiencies; their presentations, diagnoses, treatments; and, when known, the genetic defects.

Keywords: Antibody deficiency; B cell deficiency; Humoral immune deficiency; Immunoglobulin deficiency.

Publication types

Review

MeSH terms

Agammaglobulinemia / immunology
Antibody Formation / immunology
Child
Child, Preschool
Humans
Immunity, Humoral*
Immunoglobulins / deficiency*
Immunologic Deficiency Syndromes / immunology*
Infant
Infant, Newborn

Substances

Immunoglobulins