The stepwise photodamage of organelles by two-photon luminescent ruthenium(ii) photosensitizers

Kangqiang Qiu; Ya Wen; Cheng Ouyang; Xinxing Liao; Chaofeng Liu; Thomas W Rees; Qianling Zhang; Liangnian Ji; Hui Chao

doi:10.1039/c9cc05962h

The stepwise photodamage of organelles by two-photon luminescent ruthenium(ii) photosensitizers

Chem Commun (Camb). 2019 Sep 17;55(75):11235-11238. doi: 10.1039/c9cc05962h.

Authors

Kangqiang Qiu¹, Ya Wen, Cheng Ouyang, Xinxing Liao, Chaofeng Liu, Thomas W Rees, Qianling Zhang, Liangnian Ji, Hui Chao

Affiliation

¹ College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518055, P. R. China. [email protected].

PMID: 31469153
DOI: 10.1039/c9cc05962h

Abstract

Ru(ii) polypyridyl complexes, containing a morpholine moiety, and possessing two-photon absorption properties and pH dependent singlet oxygen production were used for stepwise lysosomes-to-mitochondria photodamage of cancer cells.

MeSH terms

A549 Cells
Cell Survival / drug effects
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Humans
Hydrogen-Ion Concentration
Light*
Microscopy, Confocal
Molecular Structure
Optical Imaging
Organelles / chemistry*
Photochemotherapy*
Photons*
Photosensitizing Agents / chemical synthesis
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Ruthenium / chemistry
Ruthenium / pharmacology*

Substances

Coordination Complexes
Photosensitizing Agents
Ruthenium