Abstract
The c-fos proto-oncogene is the cellular homologue of v-fos identified as the bone transforming gene of the FBJ and the FBR murine osteosarcoma viruses. We show here, using a sensitive in situ hybridization method, that the c-fos proto-oncogene is expressed in the cartilage, bone and tooth forming tissues during mouse development. This result suggests that the tumors observed after infection by the FBJ viral complex and c-fos overexpression in transgenic mice occur in those tissues in which c-fos is expressed during development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone and Bones / analysis
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Bone and Bones / embryology*
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Cartilage / analysis
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Cartilage / cytology
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Cartilage / embryology*
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Gene Expression Regulation
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Mice
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Mice, Transgenic
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Nucleic Acid Hybridization
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Odontoblasts / analysis
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Osteoblasts / analysis
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-fos
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Proto-Oncogene Proteins c-myc
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RNA, Messenger / analysis
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Tooth / analysis
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Tooth / embryology*
Substances
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-fos
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Proto-Oncogene Proteins c-myc
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RNA, Messenger