Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy

Mattijs Elschot; Kirsten Margrete Selnæs; Sverre Langørgen; Håkon Johansen; Helena Bertilsson; Torgrim Tandstad; Tone Frost Bathen

doi:10.1016/j.cpet.2019.06.003

Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy

PET Clin. 2019 Oct;14(4):487-498. doi: 10.1016/j.cpet.2019.06.003. Epub 2019 Aug 2.

Authors

Mattijs Elschot¹, Kirsten Margrete Selnæs², Sverre Langørgen², Håkon Johansen², Helena Bertilsson³, Torgrim Tandstad⁴, Tone Frost Bathen⁵

Affiliations

¹ Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, PO Box 8900, NO-7491 Trondheim, Norway; Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, PO Box 3250 Torgarden, NO-7006 Trondheim, Norway. Electronic address: [email protected].
² Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, PO Box 3250 Torgarden, NO-7006 Trondheim, Norway.
³ Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, PO Box 8900, NO-7491 Trondheim, Norway; Department of Urology, St. Olavs Hospital, Trondheim University Hospital, PO Box 3250 Torgarden, NO-7006 Trondheim, Norway.
⁴ Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, PO Box 8900, NO-7491 Trondheim, Norway; The Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, PO Box 3250 Torgarden, NO-7006 Trondheim, Norway.
⁵ Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, PO Box 8900, NO-7491 Trondheim, Norway; Department of Circulation and Medical Imaging. Norwegian University of Science and Technology, PO Box 8900, NO-7491 Trondheim, Norway.

PMID: 31472746
DOI: 10.1016/j.cpet.2019.06.003

Abstract

This article presents an overview of the current literature on PET imaging with prostate-specific membrane antigen ligands, especially focusing on the potential role of simultaneous PET/magnetic resonance imaging for the planning of salvage radiotherapy in patients with prostate cancer with biochemical recurrence after radical prostatectomy.

Keywords: MR imaging; PET; PSMA; Prostate cancer; Prostatectomy; Recurrence; Salvage radiotherapy.

Publication types

Review

MeSH terms

Aged
Biomarkers, Tumor / blood
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Multimodal Imaging / methods*
Neoplasm Invasiveness / pathology
Neoplasm Recurrence, Local / diagnostic imaging*
Neoplasm Recurrence, Local / radiotherapy
Neoplasm Staging
Positron-Emission Tomography / methods
Prognosis
Prostate-Specific Antigen / blood*
Prostatectomy / methods
Prostatic Neoplasms / diagnostic imaging*
Prostatic Neoplasms / mortality
Prostatic Neoplasms / radiotherapy*
Prostatic Neoplasms / surgery
Radiosurgery
Radiotherapy Planning, Computer-Assisted / methods*
Risk Assessment
Salvage Therapy / methods
Survival Analysis
Treatment Outcome

Substances

Biomarkers, Tumor
Prostate-Specific Antigen