When Time Matters: An Adolescent Intervention to Prevent Adult Brain Dysfunction

Sarah Canetta; Christoph Kellendonk

doi:10.1016/j.cell.2019.08.015

When Time Matters: An Adolescent Intervention to Prevent Adult Brain Dysfunction

Cell. 2019 Sep 5;178(6):1282-1284. doi: 10.1016/j.cell.2019.08.015. Epub 2019 Aug 29.

Authors

Sarah Canetta¹, Christoph Kellendonk²

Affiliations

¹ Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
² Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA; Department of Pharmacology, Columbia University Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address: [email protected].

PMID: 31474365
DOI: 10.1016/j.cell.2019.08.015

Abstract

Can we one day prevent mental disorders? Mukherjee et al. (2019) use a genetic mouse model of schizophrenia-risk with established abnormalities in adult hippocampal-prefrontal circuit function and cognitive behaviors to identify circuit-specific treatments during adolescence that prevent the onset of the adult deficits.

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MeSH terms

Adolescent
Adult
Animals
Cognitive Dysfunction*
Disease Models, Animal
Hippocampus
Humans
Mice
Prefrontal Cortex
Schizophrenia*