Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma

Vicki L Clifton; Megan McDonald; Janna L Morrison; Stacey L Holman; Mitchell C Lock; Zarqa Saif; Ashley Meakin; Amy L Wooldridge; Kathryn L Gatford; Megan J Wallace; Beverly S Muhlhausler; Robert J Bischof; Timothy J M Moss

doi:10.1016/j.placenta.2019.06.380

Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma

Placenta. 2019 Aug:83:33-36. doi: 10.1016/j.placenta.2019.06.380. Epub 2019 Jun 28.

Affiliations

¹ Pregnancy and Development, Mater Research Institute-University of Queensland, Translational Research Institute, South Brisbane, Australia. Electronic address: [email protected].
² Pregnancy and Development, Mater Research Institute-University of Queensland, Translational Research Institute, South Brisbane, Australia.
³ Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, 5001, Australia.
⁴ Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
⁵ The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, 3168, Australia.
⁶ Food and Nutrition Research Group, Dept of Food and Wine Science, The University of Adelaide, Adelaide, SA, 5005, Australia.
⁷ The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.

PMID: 31477204
DOI: 10.1016/j.placenta.2019.06.380

Abstract

Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling. Our aim was to examine the effect of maternal asthma on placental GR profiles using a pregnant sheep model of asthma. Nine known GR isoforms were detected. There was a significant increase in the expression of placental GR isoforms that are known to have low trans-activational activity in other species including GR A, GR P and GRγ which may result in a pro-inflammatory environment in the presence of allergic asthma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
Asthma / complications*
Asthma / metabolism*
Asthma / pathology
Disease Models, Animal
Female
Placenta / metabolism*
Placenta / pathology
Pregnancy
Pregnancy Complications / metabolism*
Pregnancy Complications / pathology
Protein Isoforms / classification
Protein Isoforms / metabolism
Receptors, Glucocorticoid / classification
Receptors, Glucocorticoid / metabolism*
Sheep, Domestic

Substances

Protein Isoforms
Receptors, Glucocorticoid