Abstract
Cl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium / analysis
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Calcium / metabolism
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Cell Line, Tumor
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Cell Membrane / drug effects
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Endoplasmic Reticulum / drug effects
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Endoplasmic Reticulum / metabolism
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Endoplasmic Reticulum Stress / drug effects
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Humans
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Molecular Structure
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Organic Anion Transporters / chemical synthesis
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Organic Anion Transporters / chemistry
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Organic Anion Transporters / pharmacology*
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Prodigiosin / chemical synthesis
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Prodigiosin / chemistry
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Prodigiosin / pharmacology*
Substances
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Organic Anion Transporters
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Prodigiosin
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Calcium