Membrane Lipid Remodeling Takes Center Stage in Growth Factor Receptor-Driven Cancer Development

Johannes V Swinnen; Jonas Dehairs; Ali Talebi

doi:10.1016/j.cmet.2019.08.016

Membrane Lipid Remodeling Takes Center Stage in Growth Factor Receptor-Driven Cancer Development

Cell Metab. 2019 Sep 3;30(3):407-408. doi: 10.1016/j.cmet.2019.08.016.

Authors

Johannes V Swinnen¹, Jonas Dehairs², Ali Talebi²

Affiliations

¹ Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address: [email protected].
² Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium.

PMID: 31484051
DOI: 10.1016/j.cmet.2019.08.016

Abstract

Enhanced growth factor signaling is a hallmark of cancer, allowing cancer cells to thrive in a challenging environment. In this issue of Cell Metabolism, Bi et al. (2019) identify LPCAT1, a key membrane lipid remodeling enzyme, as a central link between genetically driven growth factor receptor expression, signaling, and tumor growth, highlighting lipid remodeling as a therapeutic target in cancer.

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MeSH terms

Humans
Intercellular Signaling Peptides and Proteins
Lipid Metabolism
Membrane Lipids
Neoplasms*
Receptors, Growth Factor

Substances

Intercellular Signaling Peptides and Proteins
Membrane Lipids
Receptors, Growth Factor