Relationship between spike-wave discharges and vigilance levels in rats with spontaneous petit mal-like epilepsy

Neurosci Lett. 1988 Nov 22;94(1-2):187-91. doi: 10.1016/0304-3940(88)90293-5.

Abstract

The relationship between states of vigilance and spike and wave discharges (SWD) was examined during 12 hours in 4 Wistar rats from a strain bred for spontaneous generalized non-convulsant seizures. On the basis of cortical and hippocampal EEG and EMG activity, wakefulness (W), slow wave sleep (SWS) and paradoxical sleep (REM) were distinguished. Of the SWD 86% occurred during quiet W, 14% during the first minutes of SWS. No SWD occurred during active wakefulness and they were exceptional during REM. These results show that the states of quiet W and transitional states favour the SWD in rats with petit mal-like epilepsy, as in human petit mal.

MeSH terms

  • Animals
  • Arousal / physiology*
  • Brain / physiopathology*
  • Disease Models, Animal
  • Electroencephalography
  • Electromyography
  • Epilepsy, Absence / physiopathology*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sleep / physiology