Two new phenylpropanoid glycosides from Lagotis brachystachya Maxim and their Xanthione Oxidase inhibitions

Nat Prod Res. 2021 Jul;35(13):2131-2136. doi: 10.1080/14786419.2019.1662008. Epub 2019 Sep 9.

Abstract

Two new phenylpropanoid glycosides lagotiside C and D, along with 11 known compounds were isolated from the whole plant of Lagotis brachystachya Maxim. The structures of lagotiside C and D was elucidated on the basis of spectroscopic data analysis. Moreover, all isolated components were evalued for the inhibition on Xanthione Oxidase (XOD) activity in vitro. Results indicated that all the compounds exhibited inhibitory effects on XOD with inhibition ratio in the range of 6.35%-83.69%, which suggested that Lagotis brachystachya could be served as an XOD inhibitor.

Keywords: Lagotis brachystachya; inhibition on XOD activity; lagotiside C; lagotiside D; phenylpropanoid glycosides.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Oxidoreductases / antagonists & inhibitors*
  • Oxidoreductases / metabolism
  • Plant Extracts / chemistry
  • Plantaginaceae / chemistry*
  • Propanols / chemistry
  • Propanols / isolation & purification*

Substances

  • Enzyme Inhibitors
  • Glycosides
  • Plant Extracts
  • Propanols
  • 1-phenylpropanol
  • Oxidoreductases