Anti-β_c mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model

Allergy. 2020 Feb;75(2):475-478. doi: 10.1111/all.14041. Epub 2019 Oct 3.

Authors

Kwok Ho Yip¹, Nicholas J Wilson², Harshita Pant^{1

3}, Christopher L Brown⁴, Samantha Busfield², Milica Ng², Monther Alhamdoosh², Naomi Woodman², Mark Schembri⁵, Damon J Tumes¹, Gino Vairo², Angel F Lopez¹, Andrew D Nash², Michael J Wilson², Michele A Grimbaldeston¹, Catherine M Owczarek²

Affiliations

¹ Centre for Cancer Biology, SA Pathology and the University of South Australia, UniSA CRI, Adelaide, SA, Australia.
² Research and Development, CSL Limited, Bio21 Institute, Parkville, Vic., Australia.
³ Department of Otolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
⁴ Rhinology Clinic, Royal Victorian Eye and Ear Hospital, East Melbourne, Vic., Australia.
⁵ Department of Otolaryngology and Head & Neck Surgery, Women's and Children's Hospital, Adelaide, SA, Australia.

PMID: 31505024
DOI: 10.1111/all.14041

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / immunology*
Antibodies, Monoclonal / therapeutic use*
Cytokines / metabolism
Disease Models, Animal
Heterografts*
Humans
Mice
Mice, Transgenic
Nasal Polyps / complications*
Nasal Polyps / drug therapy*
Nasal Polyps / pathology
Receptors, Cytokine / immunology*
Rhinitis / complications*
Rhinitis / drug therapy*
Sinusitis / complications*
Sinusitis / drug therapy*
Th2 Cells / immunology
Transcriptome
Treatment Outcome

Substances

Antibodies, Monoclonal
Cytokines
Receptors, Cytokine
beta C receptor