Evaluation of a Bioengineered Honey and Its Synthetic Equivalent as Novel Staphylococcus aureus Biofilm-Targeted Topical Therapies in Chronic Rhinosinusitis

Dionyssia Papadopoulou; Alicja Dabrowska; Philip G Harries; Jeremy S Webb; Raymond N Allan; Rami J Salib

doi:10.1177/1945892419874700

Evaluation of a Bioengineered Honey and Its Synthetic Equivalent as Novel Staphylococcus aureus Biofilm-Targeted Topical Therapies in Chronic Rhinosinusitis

Am J Rhinol Allergy. 2020 Jan;34(1):80-86. doi: 10.1177/1945892419874700. Epub 2019 Sep 11.

Authors

Dionyssia Papadopoulou^{1

2

3}, Alicja Dabrowska^{4

5}, Philip G Harries³, Jeremy S Webb^{4

5}, Raymond N Allan^{4

5}, Rami J Salib^{1

2

3

5}

Affiliations

¹ Faculty of Medicine, School of Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
² Southampton NIHR Respiratory Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
³ Department of Otorhinolaryngology - Head & Neck Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁴ Faculty of Environmental & Life Sciences, School of Biological Sciences, University of Southampton, Southampton, UK.
⁵ National Biofilms Innovation Centre, University of Southampton, Southampton, UK.

PMID: 31510757
DOI: 10.1177/1945892419874700

No abstract available

Keywords: MRSA; MSSA; Staphylococcus aureus; bacteria; bioengineered honey; biofilm; chronic rhinosinusitis; reactive oxygen species; therapy; topical.

MeSH terms

Bioengineering / methods*
Biofilms / drug effects*
Chronic Disease
Honey*
Humans
Methicillin-Resistant Staphylococcus aureus / drug effects*
Methicillin-Resistant Staphylococcus aureus / growth & development
Microscopy, Confocal
Rhinitis / diagnosis
Rhinitis / microbiology
Rhinitis / therapy*
Sinusitis / diagnosis
Sinusitis / microbiology
Sinusitis / therapy*
Staphylococcal Infections / diagnosis
Staphylococcal Infections / microbiology
Staphylococcal Infections / therapy*