Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer

Sci Immunol. 2019 Sep 13;4(39):eaay7668. doi: 10.1126/sciimmunol.aay7668.

Abstract

IL-6 inhibits the expression of IL-2Rβ (CD122) in germinal center TFH cells to maintain IL-2 hyporesponsiveness (see the related Research Article by Papillion et al.).

Publication types

  • Review
  • Comment

MeSH terms

  • Germinal Center
  • Interleukin-2*
  • Interleukin-6*
  • Interleukins
  • T-Lymphocytes, Helper-Inducer

Substances

  • Interleukin-2
  • Interleukin-6
  • Interleukins