Hyponatremia and renal sodium wasting in patients receiving cisplatinum

Pediatr Hematol Oncol. 1987;4(4):337-44. doi: 10.3109/08880018709141287.

Abstract

Three children with malignant solid tumors developed hyponatremia with renal sodium wasting associated with other signs of tubular dysfunction, such as hypokalemia or hypomagnesemia, a few days after cis-diammine dichloroplatinum (CDDP) administration. The normalization of serum electrolyte disturbances was obtained with increased parenteral intakes in fluids and electrolytes, and renal sodium wasting stopped by itself a few days later.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Neoplasms / complications
  • Bone Neoplasms / drug therapy
  • Child
  • Cisplatin / adverse effects*
  • Cisplatin / therapeutic use
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyponatremia / chemically induced*
  • Hyponatremia / diagnosis
  • Ilium
  • Inappropriate ADH Syndrome / diagnosis
  • Infant
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / metabolism
  • Kidney Tubules, Proximal / drug effects
  • Kidney Tubules, Proximal / metabolism
  • Male
  • Neuroblastoma / complications
  • Neuroblastoma / drug therapy
  • Sarcoma, Ewing / complications
  • Sarcoma, Ewing / drug therapy
  • Sodium / metabolism
  • Thoracic Neoplasms / complications
  • Thoracic Neoplasms / drug therapy

Substances

  • Sodium
  • Cisplatin