Reactive lymphoid hyperplasia of the liver. A case report

Rev Esp Patol. 2019 Oct-Dec;52(4):246-249. doi: 10.1016/j.patol.2019.06.001. Epub 2019 Aug 27.

Abstract

Reactive lymphoid hyperplasia of the liver is an unusual benign lesion of unknown pathogenesis. The largest reported series to date includes only 7 cases. Reactive lymphoid hyperplasia can be radiologically confused with malignant tumors such as hepatocellular carcinoma or metastases. Histological differential diagnosis should be chiefly made with lymphomas, Castleman disease and primary biliary cirrhosis. We report the clinicopathological findings in a 54-year-old woman with an incidental hepatic lesion when she consulted for hematuria. After histological, immunohistochemical and molecular studies, the diagnosis of reactive lymphoid hyperplasia was made.

Keywords: Hepatic pseudolymphoma; Hiperplasia linfoide reactiva; Hiperplasia nodular linfoide; Lesión linfoide hepática; Liver lymphoid lesion; Nodular lymphoid hyperplasia; Reactive lymphoid hyperplasia; Seudolinfoma hepático.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers
  • Carcinoma, Hepatocellular / diagnosis
  • Castleman Disease / diagnosis
  • Diagnosis, Differential
  • Female
  • Germinal Center / chemistry
  • Germinal Center / pathology
  • Hematuria / complications
  • Humans
  • Incidental Findings
  • Liver Cirrhosis, Biliary / diagnosis
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / pathology
  • Lymphoma / diagnosis
  • Magnetic Resonance Imaging
  • Middle Aged
  • Pseudolymphoma / diagnosis*
  • Pseudolymphoma / diagnostic imaging
  • Pseudolymphoma / pathology
  • Tomography, X-Ray Computed
  • Ultrasonography

Substances

  • Biomarkers