Control and Elimination of Extensively Drug-Resistant Acinetobacter baumanii in an Intensive Care Unit

Emerg Infect Dis. 2019 Oct;25(10):1928-1931. doi: 10.3201/eid2510.181626.

Abstract

We decreased antimicrobial drug consumption in an intensive care unit in Lebanon by changing to colistin monotherapy for extensively drug-resistant Acinetobacter baumanii infections. We saw a 78% decrease of A. baumanii in sputum and near-elimination of blaoxa-23-carrying sequence type 2 clone over the 1-year study. Non-A. baumanii multidrug-resistant infections remained stable.

Keywords: Acinetobacter baumanii; France; Lebanon; MDR; XDR; antimicrobial resistance; antimicrobial stewardship; bacteria; carbapenem.

MeSH terms

  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / prevention & control*
  • Acinetobacter baumannii / drug effects*
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Antimicrobial Stewardship / methods
  • Cross Infection / drug therapy
  • Cross Infection / prevention & control*
  • Disease Eradication / methods
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Humans
  • Intensive Care Units*
  • Lebanon / epidemiology
  • Male
  • Sputum / microbiology

Substances

  • Anti-Bacterial Agents