Development of a cross-validated model for predicting emergency cesarean for intrapartum fetal compromise at term

Int J Gynaecol Obstet. 2020 Jan;148(1):41-47. doi: 10.1002/ijgo.12979. Epub 2019 Oct 16.

Abstract

Objectives: To develop a model for predicting emergency cesarean for fetal distress (ECFD) at term using a combination of maternal and late pregnancy ultrasound parameters measured at more than 36 gestational weeks.

Methods: A study of prospectively collected data, including ultrasound scans at 36-38 weeks, for singleton non-anomalous deliveries at Mater Mother's Hospital, Brisbane, Australia, between January 2010 and April 2017. Univariable and multivariable mixed-effects generalized linear models were generated. The final model was validated by the K-fold cross validation technique.

Results: Overall, 5439 women met the inclusion criteria; of these, 230 (4.2%) underwent ECFD. There were more nulliparous women and women with induction of labor (IOL) in the ECFD cohort (both P < 0.001). ECFD neonates had lower z-scores for estimated fetal weight (EFW), cerebroplacental ratio (CPR), and middle cerebral artery pulsatility index; and higher scores for umbilical artery pulsatility index. Ethnicity, nulliparity, IOL, EFW z-score, and CPR z-score were included in the final prediction model, which showed high accuracy with an area under the receiver operator characteristic curve of 0.77.

Conclusion: The study shows that a prediction model combining the continuous standardized measures of CPR and EFW and several maternal factors was able to identify ECFD with improved accuracy.

Keywords: Cerebroplacental ratio; Doppler; Emergency cesarean; Estimated fetal weight; Fetal compromise; Fetal distress.

Publication types

  • Validation Study

MeSH terms

  • Adult
  • Australia / epidemiology
  • Cesarean Section / statistics & numerical data*
  • Female
  • Fetal Distress / diagnosis*
  • Fetal Distress / epidemiology
  • Fetal Weight
  • Humans
  • Infant, Newborn
  • Middle Cerebral Artery / diagnostic imaging
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Trimester, Third
  • Prospective Studies
  • Ultrasonography, Prenatal / methods
  • Umbilical Arteries / diagnostic imaging