Viral Blips After Treatment Initiation During Acute Human Immunodeficiency Virus Infection

Trevor A Crowell; Suteeraporn Pinyakorn; Carlo Sacdalan; Eugène Kroon; Donn J Colby; Suwanna Puttamaswin; Sasiwimol Ubolyam; Rapee Trichavaroj; Oratai Butterworth; Ellen Turk; Corinne Mccullough; Nicolas Chomont; Mark de Souza; Merlin L Robb; Nittaya Phanuphak; Jintanat Ananworanich; RV254/SEARCH010 Study Group

doi:10.1093/cid/ciz936

Viral Blips After Treatment Initiation During Acute Human Immunodeficiency Virus Infection

Clin Infect Dis. 2020 Jun 10;70(12):2706-2709. doi: 10.1093/cid/ciz936.

Authors

Trevor A Crowell^{1

2}, Suteeraporn Pinyakorn^{1

2}, Carlo Sacdalan³, Eugène Kroon³, Donn J Colby³, Suwanna Puttamaswin³, Sasiwimol Ubolyam⁴, Rapee Trichavaroj⁵, Oratai Butterworth^{1

2}, Ellen Turk^{1

2}, Corinne Mccullough^{1

2}, Nicolas Chomont⁶, Mark de Souza^{2

3}, Merlin L Robb^{1

2}, Nittaya Phanuphak³, Jintanat Ananworanich^{1

2

3

7}; RV254/SEARCH010 Study Group

Affiliations

¹ US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
² Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
³ South East Asia Research Collaboration in HIV, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
⁴ The HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
⁵ Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
⁶ Centre de Recherche du Centre Hospitalier de l'Université de Montréal and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
⁷ Department of Global Health, University of Amsterdam, Amsterdam, The Netherlands.

Abstract

Transient viral blips ≥20 copies/mL were observed in 16.9% of acutely treated adults with HIV. Blip incidence increased from 0.0 (95% CI, 0.0-2.9)/100 person-years after ART in Fiebig I to 15.9 (7.6-29.2) in Fiebig V. Increasing viral load and Fiebig stage at ART initiation were independently predictive of blips.

Keywords: Thailand; acquired immunodeficiency syndrome; anti-HIV agents; antiretroviral agents; viremia.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adult
Antiretroviral Therapy, Highly Active
HIV Infections* / drug therapy
HIV-1*
Humans
Viral Load