The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects

Chemistry. 2020 Feb 17;26(10):2211-2221. doi: 10.1002/chem.201903605. Epub 2019 Nov 19.

Abstract

The synthesis, characterization and biological activity of molybdenum(IV) complexes containing Trofimenko's scorpionato ligand, hydrotris(3-isopropylpyrazolyl)borate (TpiPr ), in addition to varying biologically active as well as other conventional ligands is described. Ligands employed include (O,O-) (S,O-) (N,N-) donors that have been successfully coordinated to the molybdenum center by means of oxygen-atom transfer (OAT) reactions from the known MoVI starting material, TpiPr MoO2 Cl. The synthesized complexes were characterized by standard analytical methods and where possible by X-ray diffraction analysis. The aqueous stability of the compounds was studied by means of UV/Vis spectroscopy and the impact of the attached ligand scaffolds on the oxidation potentials (MoIV to MoV ) was studied by cyclic voltammetry. Utilizing polyvinylpyrrolidone (PVP) as a solubilizing agent, adequate aqueous solubility for biological tests was obtained. Anticancer activity tests and preliminary mode of action studies have been performed in vitro and in vivo.

Keywords: anticancer; biological tests; in vivo experiments; molybdenum; tris(pyrazolyl)borate.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Borates / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chelating Agents / chemistry
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology
  • Coordination Complexes / therapeutic use
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Drug Stability
  • Humans
  • Ligands
  • Mice
  • Mice, Inbred BALB C
  • Molecular Conformation
  • Molybdenum / chemistry*
  • Neoplasms / drug therapy
  • Nitrogen / chemistry
  • Oxygen / chemistry
  • Pyrazoles / chemistry*
  • Sulfur / chemistry

Substances

  • Antineoplastic Agents
  • Borates
  • Chelating Agents
  • Coordination Complexes
  • Ligands
  • Pyrazoles
  • tris(pyrazolyl)borate
  • Sulfur
  • Molybdenum
  • Nitrogen
  • Oxygen

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