Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

Thiago Wendt Viola; Jaqueline Bohrer Schuch; Diego Luiz Rovaris; Rafael Genovese; Lucca Tondo; Breno Sanvicente-Vieira; Aline Zaparte; Renata Basso Cupertino; Bruna Santos da Silva; Claiton Henrique Dotto Bau; Rodrigo Grassi-Oliveira

doi:10.1007/s00702-019-02086-w

Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

J Neural Transm (Vienna). 2019 Dec;126(12):1707-1711. doi: 10.1007/s00702-019-02086-w. Epub 2019 Sep 27.

Authors

Affiliations

¹ Developmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil.
² Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
³ Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
⁴ ADHD Outpatient Program, Adult Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
⁵ Department of Psychology, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
⁶ Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
⁷ Developmental Cognitive Neuroscience Lab, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Avenida Ipiranga 6691 - Predio 11, sala 926, Jardim Botânico, Porto Alegre, RS, Brazil. [email protected].

Abstract

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

Keywords: Cocaine addiction; Cognition; SNARE complex; Stimulants; Substance use disorders.

MeSH terms

Adult
Case-Control Studies
Cocaine-Related Disorders / complications*
Cognitive Dysfunction / genetics*
Cross-Sectional Studies
Female
Humans
Polymorphism, Single Nucleotide
Synaptotagmin I / genetics*

Substances

SYT1 protein, human
Synaptotagmin I

Abstract

MeSH terms

Substances

Grants and funding