Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics

Adolfo Ramirez-Zamora; James Giordano; Edward S Boyden; Viviana Gradinaru; Aysegul Gunduz; Philip A Starr; Sameer A Sheth; Cameron C McIntyre; Michael D Fox; Jerrold Vitek; Vinata Vedam-Mai; Umer Akbar; Leonardo Almeida; Helen M Bronte-Stewart; Helen S Mayberg; Nader Pouratian; Aryn H Gittis; Annabelle C Singer; Meaghan C Creed; Gabriel Lazaro-Munoz; Mark Richardson; Marvin A Rossi; Leopoldo Cendejas-Zaragoza; Pierre-Francois D'Haese; Winston Chiong; Ro'ee Gilron; Howard Chizeck; Andrew Ko; Kenneth B Baker; Joost Wagenaar; Noam Harel; Wissam Deeb; Kelly D Foote; Michael S Okun

doi:10.3389/fnins.2019.00936

Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics

Front Neurosci. 2019 Sep 12:13:936. doi: 10.3389/fnins.2019.00936. eCollection 2019.

Authors

Adolfo Ramirez-Zamora¹, James Giordano², Edward S Boyden^{3

4

5}, Viviana Gradinaru⁶, Aysegul Gunduz⁷, Philip A Starr⁸, Sameer A Sheth⁹, Cameron C McIntyre¹⁰, Michael D Fox¹¹, Jerrold Vitek¹², Vinata Vedam-Mai¹³, Umer Akbar¹⁴, Leonardo Almeida¹, Helen M Bronte-Stewart¹⁵, Helen S Mayberg¹⁶, Nader Pouratian¹⁷, Aryn H Gittis¹⁸, Annabelle C Singer¹⁹, Meaghan C Creed²⁰, Gabriel Lazaro-Munoz²¹, Mark Richardson²², Marvin A Rossi²³, Leopoldo Cendejas-Zaragoza²⁴, Pierre-Francois D'Haese²⁵, Winston Chiong²⁶, Ro'ee Gilron⁸, Howard Chizeck²⁷, Andrew Ko²⁸, Kenneth B Baker²⁹, Joost Wagenaar³⁰, Noam Harel³¹, Wissam Deeb¹, Kelly D Foote¹³, Michael S Okun¹

Affiliations

¹ Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
² Neuroethics Studies Program, Department of Neurology and Department of Biochemistry, Georgetown University Medical Center, Washington, DC, United States.
³ Media Laboratory, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
⁴ Center for Neurobiological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
⁵ Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States.
⁶ Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States.
⁷ Department of Neuroscience and Department of Biomedical Engineering and Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
⁸ Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States.
⁹ Department of Neurological Surgery, Baylor College of Medicine, Houston, TX, United States.
¹⁰ Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
¹¹ Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
¹² Department of Neurology, University of Minnesota, Minneapolis, MN, United States.
¹³ Department of Neurosurgery, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
¹⁴ Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Veterans Affairs Medical Center, Brown Institute for Brain Science, Brown University, Providence, RI, United States.
¹⁵ Department of Neurology and Department of Neurological Sciences and Department of Neurosurgery, Stanford University, Stanford, CA, United States.
¹⁶ Department of Neurology and Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
¹⁷ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
¹⁸ Biological Sciences and Center for Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, United States.
¹⁹ Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, GA, United States.
²⁰ Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States.
²¹ Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States.
²² Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
²³ Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, United States.
²⁴ Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States.
²⁵ Electrical Engineering, Vanderbilt University, Nashville, TN, United States.
²⁶ Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.
²⁷ Graduate Program in Neuroscience, Department of Electrical Engineering, University of Washington, Seattle, WA, United States.
²⁸ Department of Neurological Surgery, University of Washington, Seattle, WA, United States.
²⁹ Movement Disorders Program, Cleveland Clinic Foundation, Cleveland, OH, United States.
³⁰ Department of Neurology, Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, United States.
³¹ Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.

Abstract

The annual deep brain stimulation (DBS) Think Tank aims to create an opportunity for a multidisciplinary discussion in the field of neuromodulation to examine developments, opportunities and challenges in the field. The proceedings of the Sixth Annual Think Tank recapitulate progress in applications of neurotechnology, neurophysiology, and emerging techniques for the treatment of a range of psychiatric and neurological conditions including Parkinson's disease, essential tremor, Tourette syndrome, epilepsy, cognitive disorders, and addiction. Each section of this overview provides insight about the understanding of neuromodulation for specific disease and discusses current challenges and future directions. This year's report addresses key issues in implementing advanced neurophysiological techniques, evolving use of novel modulation techniques to deliver DBS, ans improved neuroimaging techniques. The proceedings also offer insights into the new era of brain network neuromodulation and connectomic DBS to define and target dysfunctional brain networks. The proceedings also focused on innovations in applications and understanding of adaptive DBS (closed-loop systems), the use and applications of optogenetics in the field of neurostimulation and the need to develop databases for DBS indications. Finally, updates on neuroethical, legal, social, and policy issues relevant to DBS research are discussed.

Keywords: Parkinson’s disease; Tourette syndrome; deep brain stimulation; epilepsy; neuromodulation; optogenetics; temporal dispersion; tremor.

Copyright © 2019 Ramirez-Zamora, Giordano, Boyden, Gradinaru, Gunduz, Starr, Sheth, McIntyre, Fox, Vitek, Vedam-Mai, Akbar, Almeida, Bronte-Stewart, Mayberg, Pouratian, Gittis, Singer, Creed, Lazaro-Munoz, Richardson, Rossi, Cendejas-Zaragoza, D’Haese, Chiong, Gilron, Chizeck, Ko, Baker, Wagenaar, Harel, Deeb, Foote and Okun.

Abstract

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