LIN28: A cancer stem cell promoter for immunotherapy in head and neck squamous cell carcinoma

Oral Oncol. 2019 Nov:98:92-95. doi: 10.1016/j.oraloncology.2019.09.024. Epub 2019 Sep 28.

Abstract

Lin28, a highly conserved RNA-binding protein, plays an important role in differentiation, metabolism, proliferation, pluripotency, and tumourigenicity. Lin28 overexpression promotes tumour-cell proliferation and metastasis in various human cancers, including head and neck cancer. Multiple studies demonstrate that Lin28 critically contributes to anti-tumour immunity and production of cancer stem cells in head and neck squamous cell carcinoma (HNSCC). Thus, Lin28 has potential application in HNSCC treatment.

Keywords: Cancer stem cell; Cell reprogramming; Development; Head and neck cancer; Immunotherapy; Lin28; Lin28/let-7; PD-L1; Squamous cell carcinoma; Stem cell therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor
  • Cell Self Renewal
  • Cellular Reprogramming / genetics
  • Cellular Reprogramming / immunology
  • Disease Susceptibility* / immunology
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Humans
  • Immunotherapy / methods
  • MicroRNAs / genetics
  • Neoplastic Stem Cells / immunology
  • Neoplastic Stem Cells / metabolism*
  • Neoplastic Stem Cells / pathology
  • RNA Interference
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Squamous Cell Carcinoma of Head and Neck / etiology*
  • Squamous Cell Carcinoma of Head and Neck / metabolism
  • Squamous Cell Carcinoma of Head and Neck / therapy

Substances

  • Biomarkers, Tumor
  • Lin28A protein, human
  • MicroRNAs
  • RNA-Binding Proteins
  • mirnlet7 microRNA, human