A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

Cheng Zhang; Ruilin Guan; Xinxing Liao; Cheng Ouyang; Thomas W Rees; Jiangping Liu; Yu Chen; Liangnian Ji; Hui Chao

doi:10.1039/c9cc05998a

A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

Chem Commun (Camb). 2019 Oct 25;55(83):12547-12550. doi: 10.1039/c9cc05998a. Epub 2019 Oct 2.

Authors

Cheng Zhang¹, Ruilin Guan¹, Xinxing Liao¹, Cheng Ouyang¹, Thomas W Rees¹, Jiangping Liu¹, Yu Chen¹, Liangnian Ji¹, Hui Chao²

Affiliations

¹ MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. [email protected] [email protected].
² MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. [email protected] [email protected] and College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, P. R. China.

PMID: 31576841
DOI: 10.1039/c9cc05998a

Abstract

A mitochondria-targeting hetero-binuclear Ir(iii)-Ru(ii) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.

MeSH terms

A549 Cells
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Proliferation / drug effects
Cisplatin / chemistry
Cisplatin / pharmacology
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm / drug effects*
Drug Screening Assays, Antitumor
Humans
Iridium / chemistry
Iridium / pharmacology*
Mitochondria / drug effects*
Molecular Structure
Photochemotherapy*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Ruthenium / chemistry
Ruthenium / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Coordination Complexes
Photosensitizing Agents
Iridium
Ruthenium
Cisplatin