One drug and two diseases: A case of multidrug-resistant hidradenitis suppurativa and psoriasis treated with apremilast

Dermatol Ther. 2019 Nov;32(6):e13089. doi: 10.1111/dth.13089. Epub 2019 Oct 14.

Abstract

Hidradenitis suppurativa and psoriasis are chronic inflammatory skin disorders. The onset of these pathologies is due to the interaction between genetic, environmental, and immunological factors making them classifiable as immuno-mediated inflammatory diseases, deriving from immunological deregulation. The coexistence of hidradenitis suppurativa (HS) and psoriasis in the same patient is rare and choosing the right therapy to treat both the conditions can be challenging. Here, we report the case of a patient affected by multidrug-resistant psoriasis and HS who reached a complete healing with apremilast, suggesting its possible therapeutic role in patients showing both the diseases.

Keywords: HS; PDE4-inhibitor; psoriasis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Drug Resistance, Multiple
  • Hidradenitis Suppurativa / drug therapy*
  • Hidradenitis Suppurativa / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Psoriasis / drug therapy*
  • Psoriasis / physiopathology
  • Thalidomide / analogs & derivatives*
  • Thalidomide / therapeutic use
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Thalidomide
  • apremilast