Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19

Leukemia. 2020 Apr;34(4):1202-1207. doi: 10.1038/s41375-019-0580-z. Epub 2019 Oct 7.

Mukta Asnani^#¹, Katharina E Hayer^#^{1

2}, Ammar S Naqvi^{1

2}, Sisi Zheng^{1

3}, Scarlett Y Yang¹, Derek Oldridge^{3

4}, Fadia Ibrahim⁴, Manolis Maragkakis^{4

5}, Matthew R Gazzara⁶, Kathryn L Black^{1

7}, Asen Bagashev¹, Deanne Taylor^{2

8}, Zissimos Mourelatos⁴, Stephan A Grupp^{3

8}, David Barrett^{3

8}, John M Maris^{3

8}, Elena Sotillo^{1

9}, Yoseph Barash⁶, Andrei Thomas-Tikhonenko^{10

11

12}

¹ Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
² DBHi Bioinformatics Group, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
³ Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
⁴ Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁵ Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA.
⁶ Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁷ Lonza Biologics, Portsmouth, NH, USA.
⁸ Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁹ Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
¹⁰ Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. [email protected].
¹¹ Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].
¹² Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].

^# Contributed equally.

No abstract available

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