Genomic characterization of a Klebsiella pneumoniae ST1519 resistant to ceftazidime/avibactam carrying a novel KPC variant (KPC-36)

Int J Antimicrob Agents. 2020 Jan;55(1):105816. doi: 10.1016/j.ijantimicag.2019.09.020. Epub 2019 Oct 5.

Authors

Paolo Gaibani¹, Simone Ambretti², Caterina Campoli³, PierLuigi Viale³, Maria Carla Re⁴

Affiliations

¹ Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna, Italy. Electronic address: [email protected].
² Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna, Italy.
³ Operative Unit of Infectious Diseases, S. Orsola-Malpighi University Hospital, Bologna, Italy.
⁴ Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna, Italy; University of Bologna, Bologna, Italy.

PMID: 31593765
DOI: 10.1016/j.ijantimicag.2019.09.020

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Anti-Bacterial Agents / pharmacology*
Azabicyclo Compounds / pharmacology*
Boronic Acids / pharmacology
Carrier State
Ceftazidime / pharmacology*
Drug Combinations
Drug Resistance, Multiple, Bacterial / genetics
Gene Expression Regulation, Bacterial
Genome, Bacterial
Heterocyclic Compounds, 1-Ring / pharmacology
Humans
Klebsiella Infections / drug therapy
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / genetics*
Male
Meropenem / pharmacology
Middle Aged
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Azabicyclo Compounds
Boronic Acids
Drug Combinations
Heterocyclic Compounds, 1-Ring
avibactam, ceftazidime drug combination
meropenem and vaborbactam
Ceftazidime
beta-Lactamases
Meropenem