Soccer is the most popular sport in the world, with more than 270 million participants. It is characterized by repetition of short and intense actions that require high-coordination capacity. It is a sport where interactions with other players put the athletes at risk for traumatic injuries. Lower-limb injuries are the most prevalent injuries in soccer. Spine injuries are less frequent; however, they can impose serious and debilitating sequelae on the athlete. These injuries can be associated with long recovery periods preventing return to play. Moreover, specific repetitive activities (heading, kicking, etc.) can lead to chronic injuries. The cervical spine is particularly at risk for degenerative changes. Considerations for when an athlete should undergo spinal surgery and the timing of return to play present a difficult challenge to spine specialists. The objective of this article is to review the epidemiology, diagnosis, treatment, and prevention of spinal injuries in soccer.