Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab

J Drugs Dermatol. 2019 Oct 1;18(10):1047.

Abstract

To the Editor: Acrodermatitis continua of Hallopeau (ACH) is a relatively rare chronic disorder with clinical findings of pustules and erythematous plaques on the digits.1 Although it is a variant of pustular psoriasis, it can be resistant to multiple lines of therapy. We describe for the first time a patient with recalcitrant ACH successfully treated with brodalumab, an interleukin-17 receptor A (IL-17RA) blocking antibody.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Acrodermatitis / drug therapy*
  • Acrodermatitis / immunology
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal, Humanized
  • Dermatologic Agents / administration & dosage*
  • Drug Administration Schedule
  • Drug Resistance
  • Fingers
  • Humans
  • Male
  • Middle Aged
  • Receptors, Interleukin-17 / antagonists & inhibitors
  • Receptors, Interleukin-17 / immunology
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Dermatologic Agents
  • IL17RA protein, human
  • Receptors, Interleukin-17
  • brodalumab