A Young Female With Refractory Hypertension

Urology. 2020 Jan:135:e1. doi: 10.1016/j.urology.2019.09.033. Epub 2019 Oct 8.

Abstract

A 29-year-old female was referred to the urology clinic because of an incidentally found left renal mass discovered during workup for secondary erythrocytosis. Since 12 years of age, she has had headaches and poorly controlled hypertension refractory to trimodal antihypertensive therapy. Laboratory workup revealed markedly elevated aldosterone and renin levels. Computed tomography demonstrated a 3 cm left renal mass. The patient was admitted for intravenous blood pressure control. After partial nephrectomy, aldosterone and renin levels normalized. The patient was weaned off of blood pressure medications. Pathology was consistent with a juxtaglomerular cell tumor secreting renin (ie, reninoma).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aldosterone / blood
  • Antihypertensive Agents / pharmacology*
  • Antihypertensive Agents / therapeutic use
  • Drug Resistance
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension / blood
  • Hypertension / drug therapy
  • Hypertension / etiology*
  • Juxtaglomerular Apparatus / diagnostic imaging
  • Juxtaglomerular Apparatus / metabolism
  • Juxtaglomerular Apparatus / pathology*
  • Kidney Neoplasms / complications*
  • Kidney Neoplasms / diagnosis
  • Kidney Neoplasms / surgery
  • Nephrectomy
  • Renin / blood
  • Renin / metabolism
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Aldosterone
  • Renin