Abstract
Previous work has identified selective defect(s) in T cells in mice deprived of B lymphocytes by the chronic administration of anti-IgM antibody. Experiments described in the present communication revealed that anti-IgM-treated mice do not possess T cells with surface Ia and FcR, and, unlike T cells from normal animals, they also fail to bind these molecules in vitro. Functional assays disclosed that an anti-suppressor pathway which relies on Ia+ donor and acceptor T cells is interrupted in these mice at both levels. These observations may provide an insight to explain the selective failure of some T cells when B lymphocytes have been deleted.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Anti-Idiotypic / immunology
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Antibody Formation
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B-Lymphocytes / immunology*
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Histocompatibility Antigens Class II / immunology
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Immunoglobulin M / immunology
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Lymphocyte Cooperation
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Lymphokines / immunology
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Mice
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Mice, Inbred Strains
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Prostatic Secretory Proteins*
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Receptors, Fc / immunology
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T-Lymphocytes / immunology*
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T-Lymphocytes, Regulatory / immunology
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Thymus Gland / immunology
Substances
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Antibodies, Anti-Idiotypic
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Histocompatibility Antigens Class II
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Immunoglobulin M
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Lymphokines
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Prostatic Secretory Proteins
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Receptors, Fc
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beta-microseminoprotein
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immunoglobulin-binding factors