Cases in Precision Medicine: A Personalized Approach to Stroke and Cardiovascular Risk Assessment in Women

Ann Intern Med. 2019 Dec 3;171(11):837-842. doi: 10.7326/M19-1601. Epub 2019 Oct 15.

Abstract

Cardiovascular disease is the leading cause of death among women in the United States, and stroke is third. This article uses a case scenario to examine female sex-specific cardiovascular risk factors across the lifespan and describes a precision medicine-based approach to risk factor modification and primary prevention. It also presents recent updates to the role of genetic testing and polygenic risk scores for the prediction of stroke and cardiovascular disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Aspirin / therapeutic use
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / mortality
  • Cardiovascular Diseases / prevention & control*
  • Evidence-Based Medicine
  • Female
  • Genetic Techniques
  • Humans
  • Medical History Taking
  • Middle Aged
  • Precision Medicine*
  • Primary Prevention
  • Risk Assessment / methods*
  • Risk Factors
  • Stroke / epidemiology
  • Stroke / mortality
  • Stroke / prevention & control*
  • United States / epidemiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin