Antifungal Drugs for Invasive Candida Infections (ICI) in Neonates: Future Perspectives

Iliana Bersani; Fiammetta Piersigilli; Bianca Maria Goffredo; Alessandra Santisi; Sara Cairoli; Maria Paola Ronchetti; Cinzia Auriti

doi:10.3389/fped.2019.00375

Antifungal Drugs for Invasive Candida Infections (ICI) in Neonates: Future Perspectives

Front Pediatr. 2019 Sep 20:7:375. doi: 10.3389/fped.2019.00375. eCollection 2019.

Authors

Iliana Bersani¹, Fiammetta Piersigilli¹, Bianca Maria Goffredo², Alessandra Santisi¹, Sara Cairoli², Maria Paola Ronchetti¹, Cinzia Auriti¹

Affiliations

¹ Neonatal Intensive Care Unit, Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.
² Biochemistry Laboratory, Department of Specialist Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy.

Abstract

Fungal infections may complicate the neonatal clinical course, and the spectrum of therapies for their treatment in the perinatal period is limited. Polyenes, Azoles and Echinocandins represent the three classes of antifungal drugs commonly used in the neonatal period. The present review provides an overview about the most recent therapeutic strategies for the treatment of fungal infections in neonates.

Keywords: azoles; candidemia; echinocandins; fungal infection; lock therapy; neonate; polyenes; sepsis.

Publication types

Review