Successful treatment with isavuconazole of subcutaneous phaeohyphomycosis in a kidney transplant recipient

Transpl Infect Dis. 2019 Dec;21(6):e13197. doi: 10.1111/tid.13197. Epub 2019 Oct 30.

Abstract

Phaeohyphomycosis is a diverse group of uncommon mycotic infections caused by dematiaceous fungi which appears to be increasing in incidence, particularly in transplant recipients. Alternaria is the most frequent isolated genus. Subcutaneous, pulmonary and disseminated disease are the most common sites of Alternaria infection in solid organ transplant recipients. We report the first case, to our knowledge, of a kidney transplant recipient with Alternaria alternata subcutaneous infection who was successfully treated with isavuconazole.

Keywords: Alternaria; Phaeohyphomycosis; isavuconazole; transplantation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alternaria / immunology
  • Alternaria / isolation & purification
  • Antifungal Agents / therapeutic use*
  • Humans
  • Immunocompromised Host
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation / adverse effects*
  • Male
  • Nitriles / therapeutic use*
  • Phaeohyphomycosis / diagnosis
  • Phaeohyphomycosis / drug therapy*
  • Phaeohyphomycosis / microbiology
  • Pyridines / therapeutic use*
  • Subcutaneous Tissue / microbiology*
  • Treatment Outcome
  • Triazoles / therapeutic use*

Substances

  • Antifungal Agents
  • Nitriles
  • Pyridines
  • Triazoles
  • isavuconazole