Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma

Kevin J Selva; Benjamin R Bavinton; Andrew E Grulich; Marzena Pazgier; Anthony D Kelleher; Stephen J Kent; Matthew S Parsons

doi:10.1002/eji.201848055

Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma

Eur J Immunol. 2019 Dec;49(12):2255-2258. doi: 10.1002/eji.201848055. Epub 2019 Nov 13.

Authors

Kevin J Selva¹, Benjamin R Bavinton², Andrew E Grulich², Marzena Pazgier³, Anthony D Kelleher², Stephen J Kent^{1

4

5}, Matthew S Parsons^{1

6

7}

Affiliations

¹ Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
² The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
³ Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
⁴ Melbourne Sexual Health Centre and Infectious Disease Department, Alfred Health, Monash University Central Clinical School, Melbourne, Victoria, Australia.
⁵ ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Melbourne, Parkville, Victoria, Australia.
⁶ Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
⁷ Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.

PMID: 31621073
DOI: 10.1002/eji.201848055

Abstract

Semen from HIV-1-infected men contains anti-HIV-1 antibodies and immunosuppressive factor(s). We assessed if suppression of viremia with antiretroviral therapy impacted seminal plasma immunosuppressive capacity or the Fc-dependent functions of seminal anti-HIV-1 antibodies. We also tested if active bacterial sexually transmitted infections altered the immunosuppressive capacity of seminal plasma.

Keywords: Fc-dependent functions; HIV-1; IgG; NK cells; semen.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Retroviral Agents / administration & dosage*
HIV Antibodies / immunology*
HIV Infections* / drug therapy
HIV Infections* / immunology
HIV Infections* / pathology
HIV-1 / immunology*
Humans
Immune Tolerance*
Male
Semen / immunology*
Seminal Plasma Proteins / immunology*
Viremia* / drug therapy
Viremia* / immunology

Substances

Anti-Retroviral Agents
HIV Antibodies
Seminal Plasma Proteins