Copper(I) Complex Mediated Nitric Oxide Reductive Coupling: Ligand Hydrogen Bonding Derived Proton Transfer Promotes N2O(g) Release

J Am Chem Soc. 2019 Nov 13;141(45):17962-17967. doi: 10.1021/jacs.9b07286. Epub 2019 Oct 29.

Abstract

A cuprous chelate bearing a secondary sphere hydrogen bonding functionality, [(PV-tmpa)CuI]+, transforms NO(g) to N2O(g) in high-yields in methanol. Ligand derived proton transfer facilitates N-O bond cleavage of a putative hyponitrite intermediate releasing N2O(g), underscoring the crucial balance between H-bonding capabilities and acidities in (bio)chemical NO(g) coupling systems.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Coordination Complexes / chemistry*
  • Copper / chemistry
  • Hydrogen Bonding
  • Ligands
  • Nitric Oxide / chemistry*
  • Nitrous Oxide / chemical synthesis*
  • Oxidation-Reduction
  • Protons

Substances

  • Coordination Complexes
  • Ligands
  • Protons
  • Nitric Oxide
  • Copper
  • Nitrous Oxide