Objective:The results of the detection of the serum inhalant allergen in children with adenoid hypertrophy in Yantai were analyzed, and the common inhalant allergens and their distribution in the children with adenoid hypertrophy were found. Method:Serum inhaled allergen specific IgE（sIgE） was measured in 590 cases of adenoid hypertrophy from Nov 2017 to Oct 2018 by Symer allergen detection system, and stratified according to sex, age and visiting season. The distribution of inhaled allergens in serum of children with adenoid hypertrophy was described. Result:The positive rate of serum inhaled allergens in children with adenoid hypertrophy in Yantai area was 34.07%. Among them the most common inhaled allergens were dust mite（19.66%）, dust mite（18.98%） and the mixed mold（17.97%）. The positive degree of allergen in children with adenoid hypertrophy was mild（93 cases）, moderate（88 cases）, and severe（20 cases）. 76 cases were positive for single allergens, 79 cases were positive for 2 allergens, and 56 cases were positive for three or more allergens. Stratified study showed that there was no significant difference in the positive rate of inhaled allergens between male and female children（P>0.05）, but the positive rate of mixed mold and animal dandruff allergens in male children was higher than that in female children（P<0.05）. There was no significant difference in the positive rate of inhaled allergens between pre-school and school-age children（P>0.05）, and there was no significant difference in the positive rate of inhaled allergens in different seasons（P>0.05）. Conclusion:Dust mite, dust mite and mildew mixture were the most common inhaled allergens in children with adenoid hypertrophy in Yantai area. The positive degree of serum allergens in children with adenoid hypertrophy was mild to moderate, and most of the children were allergic to two kinds of allergens. Male children were more susceptible to mold mixing and animal dandruff. There was no significant difference in age and seasonal distribution of common inhaled allergens.
目的：分析烟台地区腺样体肥大患儿血清吸入性变应原检测结果，了解腺样体肥大患儿常见吸入性变应原及其分布规律。 方法：测定烟台地区2017-11-2018-10期间590例腺样体肥大患儿血清中常见吸入性变应原特异性IgE（sIgE）浓度，根据患儿性别、年龄、就诊时间分组，描述腺样体肥大患儿血清中吸入性变应原的分布特征。 结果：烟台地区腺样体肥大患儿血清吸入性变应原阳性率为34.07%（201例），其中最常见的吸入性变应原为粉尘螨（19.66%）、屋尘螨（18.98%）、真菌混合（17.97%）。腺样体肥大患儿变应原阳性程度多为轻度（93例）及中度（88例），重度者（20例）较少。单种变应原阳性患儿有76例，2种变应原阳性患儿有79例，3种及3种以上变应原阳性患儿有56例。分组研究显示，男、女性患儿吸入性变应原阳性率无明显差异（P>0.05），但男性患儿中真菌混合及动物皮毛屑变应原阳性率高于女性（P<0.05）；学龄前组与学龄期组患儿吸入性变应原阳性率无明显差异（P>0.0.05）；不同季节就诊患儿吸入性变应原阳性率无明显差异（P>0.05）。 结论：粉尘螨、屋尘螨、真菌混合是烟台地区腺样体肥大患儿最常见的吸入性变应原，患儿血清吸入性变应原阳性程度多为轻中度，多数患儿对2种及2种以下变应原过敏，男性患儿更容易对真菌混合及动物皮毛屑过敏，常见吸入性变应原在年龄、季节分布上无明显差异。.
Keywords: adenoid hypertrophy; child; immunoglobulin E; inhaled allergens.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.