Bioinspired artificial platelets for transfusion applications in traumatic hemorrhage

Transfusion. 2020 Feb;60(2):229-231. doi: 10.1111/trf.15543. Epub 2019 Oct 18.

Abstract

Among blood components, platelets (PLTs) present the toughest logistic challenges in transfusion due to limited availability, difficult portability and storage, high contamination risks, and very short shelf life (approx. 5 days). Robust research efforts are being directed to develop biologic PLTs in vitro as well as design biosynthetic and artificial PLT technologies that can potentially resolve these challenges to allow adequate availability and timely transfusion to improve survival in trauma.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Blood Platelets / metabolism
  • Hemorrhage / metabolism
  • Hemorrhage / therapy*
  • Humans
  • Logistic Models
  • Platelet Transfusion / methods*
  • Wounds and Injuries / metabolism
  • Wounds and Injuries / therapy*