Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms

Noa Liberman; Simon Yuan Wang; Eric Lieberman Greer

doi:10.1016/j.conb.2019.09.012

Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms

Curr Opin Neurobiol. 2019 Dec:59:189-206. doi: 10.1016/j.conb.2019.09.012. Epub 2019 Oct 18.

Authors

Noa Liberman¹, Simon Yuan Wang¹, Eric Lieberman Greer²

Affiliations

¹ Division of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA.
² Division of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA. Electronic address: [email protected].

Abstract

Inherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related transgenerational epigenetic inheritance and delineate potential molecular mechanisms that could regulate how non-genetic information could be transmitted.

Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms

Authors

Affiliations

Abstract

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