Monosomy 5 in acute megakaryoblastic leukemia. Report of two cases

Cancer Genet Cytogenet. 1988 Jul 1;33(1):111-7. doi: 10.1016/0165-4608(88)90056-8.

Abstract

Two cases of acute megakaryoblastic leukemia are reported. The diagnoses were confirmed by clinical, morphologic, and cytochemical analysis. Karyotypic analysis demonstrated monosomy 5 in both patients, providing further evidence that acute megakaryoblastic leukemia is a subset of the acute nonlymphocytic leukemias and may be etiologically related to the myelodysplastic syndromes.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 5*
  • Female
  • Genetic Markers*
  • Humans
  • Karyotyping
  • Leukemia, Megakaryoblastic, Acute / genetics*
  • Leukemia, Megakaryoblastic, Acute / pathology
  • Male
  • Middle Aged
  • Monosomy*

Substances

  • Genetic Markers