Propofol Total Intravenous Anesthesia as an Intervention for Severe Radiation-Induced Phantosmia in an Adolescent with Ependymoma

J Adolesc Young Adult Oncol. 2020 Apr;9(2):299-302. doi: 10.1089/jayao.2019.0103. Epub 2019 Oct 23.

Abstract

Radiation-induced phantosmia has been reported both in children and adults. A fraction of these patients have nausea and vomiting triggered by phantosmia. Radiation-induced phantosmia, although transient, can be distressing enough to prevent a patient from staying still during radiation therapy. To date, specific interventions for radiation-induced phantosmia, including anesthesia, have not been reported. We report for the first time anesthesia as an intervention for transient severe radiation-induced phantosmia, in a 16-year-old girl with ependymoma undergoing proton therapy, and we discuss the pros and cons of techniques for anesthesia and airway management.

Keywords: pediatric anesthesia; phantosmia; propofol; proton therapy.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anesthesia, Intravenous / methods*
  • Ependymoma / drug therapy*
  • Female
  • Humans
  • Hypnotics and Sedatives / pharmacology
  • Hypnotics and Sedatives / therapeutic use*
  • Olfaction Disorders / chemically induced*
  • Propofol / pharmacology
  • Propofol / therapeutic use*
  • Radiotherapy / adverse effects*

Substances

  • Hypnotics and Sedatives
  • Propofol

Supplementary concepts

  • Familial ependymoma