Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

Yaron Carmi; Tyler Prestwood; Edgar G Engleman

doi:10.1080/2162402X.2015.1078063

Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity

Oncoimmunology. 2018 May 7;8(10):e1078063. doi: 10.1080/2162402X.2015.1078063. eCollection 2019.

Authors

Yaron Carmi¹, Tyler Prestwood¹, Edgar G Engleman¹

Affiliation

¹ School of Medicine, Department of Pathology, Stanford University, Palo Alto, CA, USA.

Abstract

The factors that determine the impact of antitumor antibodies on tumor progression are poorly defined. We found that the tumor microenvironment holds the key. In the absence of dendritic cell (DC) stimulation, such antibodies provide little benefit, but in a stimulatory context they can initiate potent antitumor immunity.

Keywords: Dendritic cells; Fc receptors; Tumor-binding antibodies.