Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air

Orestes A Carpaij; Susan Muiser; Alex J Bell; Huib A M Kerstjens; Craig J Galban; Aleksa B Fortuna; Salman Siddiqui; Anna-Carin Olin; Martijn C Nawijn; Maarten van den Berge

doi:10.1183/23120541.00202-2019

Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air

ERJ Open Res. 2019 Oct 21;5(4):00202-2019. doi: 10.1183/23120541.00202-2019. eCollection 2019 Oct.

Authors

Orestes A Carpaij^{1

2}, Susan Muiser¹, Alex J Bell³, Huib A M Kerstjens^{1

2}, Craig J Galban⁴, Aleksa B Fortuna⁴, Salman Siddiqui³, Anna-Carin Olin⁵, Martijn C Nawijn^{1

6}, Maarten van den Berge^{1

2}

Affiliations

¹ University of Groningen, University Medical Center Groningen, Dept of Pulmonology, Groningen, The Netherlands.
² University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
³ NIHR Biomedical Research Centre, Respiratory Theme and Dept of Respiratory Sciences, University of Leicester, Leicester, UK.
⁴ University of Michigan, Dept of Radiology, Ann Arbor, MI, USA.
⁵ Occupational and Environmental Medicine, Dept of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
⁶ University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Groningen, The Netherlands.

Abstract

PExA mass can distinguish asthmatics from healthy individuals. Subjects with complete, but not clinical, asthma remission exhale more PExA mass compared to asthma. Higher PExA mass was associated with better function of both the small and large airways. http://bit.ly/2znHABg.

Grants and funding

R01 HL139690/HL/NHLBI NIH HHS/United States