Comparative in vitro activity of imipenem against gram-positive and gram-negative aerobic bacteria from clinical isolates

Microbiologica. 1988 Apr;11(2):137-42.

Abstract

Imipenem is a member of a new class of beta-lactam antibiotics, carbapenems, with a very broad antibacterial spectrum. In this work we evaluated the in vitro activity of imipenem against a variety of bacterial strains isolated from clinical specimens as well as the activity of other beta-lactam antibiotics. The results obtained with 501 bacterial strains show that imipenem is active on both gram-negative and gram-positive microorganisms isolated from different infections. The in vitro inhibitory activity is greater than that of aztreonam, cefotaxime, ceftriaxone, piperacillin, amikacin, and netilmicin, against the majority of strains tested.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Infections / microbiology
  • Drug Resistance, Microbial
  • Gram-Negative Aerobic Bacteria / drug effects*
  • Gram-Negative Aerobic Bacteria / isolation & purification
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Imipenem
  • Microbial Sensitivity Tests
  • Thienamycins / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Thienamycins
  • Imipenem