Vitamin D and the intestine: Review and update

J Steroid Biochem Mol Biol. 2020 Feb:196:105501. doi: 10.1016/j.jsbmb.2019.105501. Epub 2019 Oct 23.

Abstract

The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH)2D3 action in the intestine and highlighting the importance of 1,25(OH)2D3 action across the proximal/distal and crypt/villus axes in the intestine is summarized.

Keywords: 1,25-dihydroxyvitamin D3; Calbindin-D; Crypt, SLC30A10; Intestine; Plasma membrane calcium pump PMCA1b; Transient receptor potential vanilloid type-6; Villus.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Channels / genetics
  • Calcium Channels / metabolism
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism
  • Gene Expression Regulation / drug effects
  • Humans
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / physiopathology
  • Intestines / drug effects
  • Intestines / physiology*
  • Receptors, Calcitriol / physiology
  • Vitamin D / pharmacology
  • Vitamin D / physiology*
  • Vitamin D Deficiency / pathology
  • Vitamin D Deficiency / physiopathology

Substances

  • Calcium Channels
  • Calcium-Binding Proteins
  • Receptors, Calcitriol
  • Vitamin D
  • Calcium