Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications

Mai Lin; Vincenzo Paolillo; Robert T Ta; Jossana Damasco; Raniv Dawey Rojo; James C Carl; Marites P Melancon; Gregory C Ravizzini; Dao B Le; Elmer B Santos

doi:10.1016/j.apradiso.2019.108936

Fully automated preparation of ⁶⁸Ga-PSMA-11 at curie level quantity using cyclotron-produced ⁶⁸Ga for clinical applications

Appl Radiat Isot. 2020 Jan:155:108936. doi: 10.1016/j.apradiso.2019.108936. Epub 2019 Oct 11.

Authors

Affiliations

¹ Cyclotron Radiochemistry Facility, The University of Texas MD Anderson Cancer Center, Houston, 77054, TX, United States. Electronic address: [email protected].
² Cyclotron Radiochemistry Facility, The University of Texas MD Anderson Cancer Center, Houston, 77054, TX, United States.
³ Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, United States.
⁴ Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, United States; College of Medicine, University of the Philippines Manila, Manila, 1000, Philippines.
⁵ Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, United States.
⁶ Cyclotron Radiochemistry Facility, The University of Texas MD Anderson Cancer Center, Houston, 77054, TX, United States; Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, United States.

PMID: 31655351
DOI: 10.1016/j.apradiso.2019.108936

Abstract

⁶⁸Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of ⁶⁸Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available ⁶⁸Ge/⁶⁸Ga generator. ⁶⁸Ge/⁶⁸Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of ⁶⁸Ga/⁶⁸Ge generators has not been able to meet the increasing demand of ⁶⁸Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing ⁶⁸Ga-PSMA-11, using cyclotron-produced ⁶⁸Ga that is ready for routine clinical practice.

Keywords: (68)Ga-PSMA-11; Automation; Cyclotron; PET/CT; cGMP.

Published by Elsevier Ltd.

MeSH terms

Automation
Cell Line, Tumor
Cyclotrons*
Gallium Isotopes
Gallium Radioisotopes
Humans
Male
Membrane Glycoproteins / chemistry*
Organometallic Compounds / chemistry*

Substances

Gallium Isotopes
Gallium Radioisotopes
Membrane Glycoproteins
Organometallic Compounds
gallium 68 PSMA-11